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KMID : 0545120050150010136
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Journal of Microbiology and Biotechnology
2005 Volume.15 No. 1 p.136 ~ p.140
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Hypoglycemic Effect of Collybia confluens Exobiopolymer Produced by Submerged Mycelial Culture on Diabetic Rats
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Yang BK
Lee HJ/Jeong SC/Lim WJ/Song CH
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Abstract
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The hypoglycemic effect of Collybia confluens exobiopolymer was investigated in streptozotocin (STZ)-induced diabetic rats. In a dose-dependent study the exobiopolymer at 150 mg/kg body weight (BW) dose substantially lowered the plasma glucose level by 29.3% as compared to the control group. It also lowered the plasma total cholesterol and triglyceride levels by 23.3 and 30.7% respectively and reduced the liver total cholesterol and triglyceride levels by 23.0 and 33.5% respectively. The activity of alanine transaminase (ALT) and aspartate transaminase (AST) was reduced 34.6% and 23.6% respectively by the exobiopolymer administration compared to the control group. The exobiopolymer was found to contain 83.2% carbohydrate and 16.8% protein. The sugar and amino acid of the exobiopolymer were also analyzed in detail.
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